Nanocurcumin - a great, natural supplement for autoimmune Diseases? Powerful, anti-Inflammatory & Immune-regulating

Could Nanocurcumin Help Support a Balanced Immune Response in Autoimmune Disease?

 The answer is possibly and maybe even probably! As written by me, Dr. Conor Kerley, leading clinician, multi-award winning nutrition research, autoimmune expert and living well over half my life with an autoimmune disease (multiple sclerosis)

 

• Nanocurcumin has much potential in Autoimmune Diseases…helping to take a person from Inflammation to Immune Regulation!
• Autoimmune diseases are characterised by inflammation and dysregulated immunity
• Curcumin is a powerful anti-inflammatory and immune regulation compound
• Nanocurcumin is a superior form of curcumin with much greater absorption - up to 100 times greater bioavailability! 
• Nanocurcumin has much potential for improving all or most autoimmune diseases
• There are even clinical trials reporting benefit of curcumin and especially nanocurcumin in at least 10 different autoimmune diseases (Hashimoto's, Psoriasis, Rheumatoid arthritis, IBD i.e. Crohn’s and Ulcerative colitis,  MS, Lupus, Ankylosing spondylitis, Arteritis, lichen planus, Behçet's)

 

Autoimmune diseases include:

 

Thyroid, endocrine & metabolic autoimmune diseases

·       Addison's disease / autoimmune adrenalitis

• Hashimoto's thyroiditis/Hashimoto's disease
• Graves' disease
• Type 1 diabetes mellitus (T1DM)
• Latent autoimmune diabetes in adults (LADA)

Rheumatological & connective-tissue autoimmune diseases

• Ankylosing spondylitis
• Antiphospholipid syndrome (APS)
• Arteritis
• Axial spondyloarthritis
• Behçet's disease
• Juvenile idiopathic arthritis
• Psoriatic arthritis
• Rheumatoid arthritis (RA)
• Sjögren's disease
• Systemic lupus erythematosus (SLE)
• Systemic sclerosis / scleroderma

Neurological autoimmune diseases

• Multiple sclerosis (MS)
• Neuromyelitis optica spectrum disorder (NMOSD)
• MOG antibody disease (MOGAD)
• Myasthenia gravis
• Guillain-Barré syndrome

Blood autoimmune disease

• Pernicious anemia
• Hemolytic anemia 
• Thrombocytopenia (ITP)
• Neutropenia
• Lymphoproliferative syndrome (ALPS)

Heart & blood vessel autoimmune diseases

·      Myocarditis

·      Pericarditis

·      Rheumatic heart disease

·      Antiphospholipid syndrome

·      Arteritis

·      Behçet's disease

·      Kawasaki disease

• Vasculitis

Gastrointestinal autoimmune diseases

• Coeliac/ celiac disease
• Crohn's disease
• Ulcerative colitis
• Autoimmune gastritis
• Pernicious anemia
• Autoimmune hepatitis
• Primary biliary cholangitis (PBC)
• Primary sclerosing cholangitis (PSC)*

🧴 Skin & hair autoimmune disease

• Alopecia
• Vitiligo
• Psoriasis
• Psoriatic arthritis
• Lichen planus

Eye diseases autoimmune diseases

• Uveitis
  Optic neuritis

 

There are clinical trials reporting benefit of curcumin and especially nanocurcumin in at least 10 different autoimmune diseases, including:

1. Hashimoto's thyroiditis and nanocurcumin
2. Psoriasis and nanocurcumin
3. Rheumatoid arthritis (RA) and nanocurcumin
4. Inflammatory bowel diseases (Crohn's disease or Ulcerative colitis) and nanocurcumin
5. Multiple sclerosis (MS) and nanocurcumin
6. Systemic lupus erythematosus (SLE) and nanocurcumin
7. Ankylosing spondylitis and nanocurcumin
8. Arteritis (Takayasu arteritis) and nanocurcumin
9. Lichen planus and nanocurcumin
10. Behçet's disease and nanocurcumin

 

Note, there may not be human clinical trials of nanocurcumin supplementation in other autoimmune diseases…But

·      There are further studies reporting benefit of curcumin in autoimmunity in cell studies

·      There are further studies reporting benefit of curcumin in autoimmunity in animal studies

·      There are further studies reporting benefit of curcumin in reducing inflammation and balancing the immune system in humans

 

A 2022 scientific review of 32 human studies regarding curcumin and 10 autoimmune disease concluded that: Curcumin had good clinical efficacy in the treatment of Psoriasis, UC and RA, so Curcumin and Curcuma longa Extract could be used in the treatment of the above diseases in the future. This review focused on 3 autoimmune diseases because the other 7 autoimmune disease did not have enough research, not because curcumin was not effective.  

 

Therefore, nano curcumin could benefit overall autoimmunity with anti-inflammatory and immune regulating effects.

There is evidence that the following are also autoimmune:

·      Allergies

·      Asthma

·      Eczema/atopic dermatitis

·      Endometriosis

·      Fibromyalgia

·      Hidradenitis suppurativadebated

·      IBS

·      Long COVID

·      ME/CFS

·      PCOS/PMOS

·      PMOS/PCOS

·      POTS

·      Rosacea

 

Regarding nutrients and autoimmune diseases, in addition to nanocurcumin, some other nutrients have documented benefits:

• Vitamin D3 – already found in gold standard curcumin
• Omega 3 – available with nanocurcumin as our inflammation/immune bundle

 

The following are less common autoimmune diseases:

·      Acquired hemophilia A

·      Acquired von Willebrand syndrome

·      Adult-onset Still's disease

·      Alopecia totalis

·      Alopecia universalis

·      ANCA-associated glomerulonephritis

·      ANCA-associated vasculitis

·      Anti-AMPA receptor encephalitis

·      Anti-GABA-B receptor encephalitis

·      Anti-GBM disease/Goodpasture disease

·      Anti-NMDA receptor encephalitis

·      Antiphospholipid syndrome

·      Antisynthetase syndrome

·      Autoimmune aplastic anemia

·      Autoimmune autonomic ganglionopathy

·      Autoimmune cerebellar ataxia

·      Autoimmune cholangitis

·      Autoimmune encephalitis

·      Autoimmune enteropathy

·      Autoimmune epilepsy

·      Autoimmune gastrointestinal dysmotility

·      Autoimmune hepatitis type 1

·      Autoimmune hepatitis type 2

·      Autoimmune hepatitis type 3

·      Autoimmune infertility/ infertility associated with antisperm antibodies

·      Autoimmune inner ear disease (AIED)

·      Autoimmune intestinal pseudo-obstruction

·      Autoimmune limbic encephalitis

·      Autoimmune myocarditis

·      Autoimmune optic neuritis

·      Autoimmune orbital inflammation

·      Autoimmune orchitis

·      Autoimmune ovarian insufficiency/primary ovarian insufficiency

·      Autoimmune overlap syndromes, such as:  AIH-PBC overlap or AIH-PSC overlap

·      Autoimmune pancreatitis

·      Autoimmune pericarditis

·      Autoimmune progesterone dermatitis

·      Autoimmune psychosis

·      Autoimmune pulmonary alveolar proteinosis

·      Autoimmune pulmonary capillaritis

·      Autoimmune pure red cell aplasia

·      Autoimmune retinopathy

·      Autoimmune sensorineural hearing loss

·      Autoimmune small-fiber neuropathy

·      Autoimmune thyroid disease affecting pregnancy

·      Autoimmune transverse myelitis

·      Autoimmune tubulointerstitial nephritis

·      Autoimmune urticaria

·      Autoimmune-associated cardiomyopathy

·      Autoimmune-associated mood disorders

·      Behçet's disease

·      Birdshot chorioretinopathy

·      Bullous pemphigoid

·      CASPR2 encephalitis

·      Chronic inflammatory demyelinating polyneuropathy (CIDP)

·      Cogan syndrome

·      Cold agglutinin disease

·      Common variable immunodeficiency (CVID) with autoimmune manifestations

·      Cryoglobulinemic glomerulonephritis

·      Cryoglobulinemic vasculitis

·      Cutaneous lupus

·      Dermatitis herpetiformis

·      Dermatomyositis

·      Diffuse cutaneous systemic sclerosis

·      Discoid lupus

·      Enteropathic arthritis

·      Eosinophilic fasciitis

·      Eosinophilic gastroenteritis

·      Eosinophilic granulomatosis with polyangiitis

·      Eosinophilic oesophagitis

·      Epidermolysis bullosa acquisita

·      Evans syndrome

·      Focal segmental glomerulosclerosis

·      GAD65-associated neurological disease

·      Giant cell arteritis

·      Giant cell myocarditis

·      Good syndrome

·      Granulomatosis with polyangiitis

·      Hashimoto's encephalopathy / SREAT

·      SREAT/ Hashimoto's encephalopathy

·      Hidradenitis suppurativa

·      IgA nephropathy

·      IgA vasculitis

·      IgG4-related autoimmune/immune-mediated cholangitis

·      IgG4-related disease

·      Immune-mediated necrotising myopathy

·      Inclusion body myositis

·      Interstitial lung disease associated with connective-tissue disease

·      Juvenile dermatomyositis

·      Juvenile idiopathic arthritis

·      Juvenile psoriatic arthritis

·      Juvenile Sjögren's disease

·      Juvenile systemic lupus

·      Juvenile systemic sclerosis

·      Kawasaki disease

·      Lambert-Eaton myasthenic syndrome

·      Leukocytoclastic/hypersensitivity vasculitis

·      LGI1 encephalitis

·      Lichen sclerosis

·      Oral lichen planus

·      Limited cutaneous systemic sclerosis

·      Linear IgA bullous dermatosis

·      Lupus arthritis

·      Lupus myocarditis

·      Lupus nephritis

·      Lymphocytic interstitial pneumonia associated with Sjögren's

·      Membranous nephropathy

·      Microscopic colitis

·      Microscopic polyangiitis

·      Minimal change disease

·      Mixed connective tissue disease (MCTD)

·      Mooren ulcer

·      Morphea / localized scleroderma

·      Mucous membrane pemphigoid

·      Multifocal motor neuropathy

·      Multiple evanescent white dot syndrome

·      Narcolepsy type 1

·      Necrotising autoimmune myopathy

·      Neonatal autoimmune myasthenia gravis

·      Neonatal lupus

·      Ocular cicatricial pemphigoid

·      Palindromic rheumatism

·      Paraneoplastic pemphigus

·      Paroxysmal cold hemoglobinuria

·      Paroxysmal nocturnal hemoglobinuria (PNH)

·      Pauci-immune glomerulonephritis

·      Pediatric acute-onset neuropsychiatric syndrome (PANS)

·      Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS)

·      Pemphigoid gestationis

·      Pemphigoid gestationis

·      Pemphigus foliaceus

·      Pemphigus herpetiformis

·      Pemphigus vulgaris

·      PERM (progressive encephalomyelitis with rigidity and myoclonus)

·      Polyarteritis nodosa

·      Polymyositis

·      Primary biliary cholangitis

·      Primary sclerosing cholangitis

·      Pyoderma gangrenosum

·      Reactive arthritis

·      Recurrent pregnancy loss associated with antiphospholipid syndrome

·      Relapsing polychondritis

·      Rheumatic fever

·      Rheumatic heart disease

·      Sjögren-associated inflammatory arthritis

·      Sjögren-associated interstitial nephritis

·      Sjögren-associated ocular disease

·      Some cases of autoimmune encephalitis presenting primarily with psychiatric symptoms

·      Stiff-person syndrome

·      Subacute cutaneous lupus

·      Susac syndrome

·      Sympathetic ophthalmia

·      Systemic juvenile idiopathic arthritis

·      Systemic sclerosis

·      Takayasu arteritis

·      Thyroid eye disease / Graves' orbitopathy

·      Undifferentiated connective tissue disease (UCTD)

·      Undifferentiated spondyloarthritis

·      Vogt-Koyanagi-Harada disease

·      Warm autoimmune hemolytic anemia

·      Autoimmune cytopenias

·      Autoimmune encephalitis

·      Autoimmune enteropathy

·      Autoimmune lymphoproliferative syndrome

·      Autoimmune polyendocrine syndromes