Rheumatoid arthritis (RA) and nanocurcumin

Dr. Conor Kerley
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Preliminary study on antirheumatic activity of curcumin (diferuloyl methane).

Deodhar SD, Sethi R, Srimal RC.Indian J Med Res. 1980 Apr;71:632-4.
A randomized, pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis.
Chandran B, Goel A.Phytother Res. 2012 Nov;26(11):1719-25. doi: 10.1002/ptr.4639. Epub 2012 Mar 9.

Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials.
Daily JW, Yang M, Park S.J Med Food. 2016 Aug;19(8):717-29. doi: 10.1089/jmf.2016.3705.

A Novel Highly Bioavailable Curcumin Formulation Improves Symptoms and Diagnostic Indicators in Rheumatoid Arthritis Patients: A Randomized, Double-Blind, Placebo-Controlled, Two-Dose, Three-Arm, and Parallel-Group Study.
Amalraj A, Varma K, Jacob J, Divya C, Kunnumakkara AB, Stohs SJ, Gopi S.J Med Food. 2017 Oct;20(10):1022-1030. doi: 10.1089/jmf.2017.3930. Epub 2017 Aug 29.

Effect of curcumin nanomicelle on the clinical symptoms of patients with rheumatoid arthritis: A randomized, double-blind, controlled trial.
Javadi M, Khadem Haghighian H, Goodarzy S, Abbasi M, Nassiri-Asl M.Int J Rheum Dis. 2019 Oct;22(10):1857-1862. doi: 10.1111/1756-185X.13688. Epub 2019 Sep 3.

Immunomodulatory therapeutic effects of curcumin in rheumatoid arthritis.
Mohammadian Haftcheshmeh S, Momtazi-Borojeni AA.Autoimmun Rev. 2020 Aug;19(8):102593. doi: 10.1016/j.autrev.2020.102593. Epub 2020 Jun 12.

Effects of curcumin supplementation on metabolic parameters, inflammatory factors and obesity values in women with rheumatoid arthritis: A randomized, double-blind, placebo-controlled clinical trial.
Pourhabibi-Zarandi F, Rafraf M, Zayeni H, Asghari-Jafarabadi M, Ebrahimi AA.Phytother Res. 2022 Apr;36(4):1797-1806. doi: 10.1002/ptr.7422. Epub 2022 Feb 17.

Curcumin and rheumatoid arthritis: A systematic review of literature.
Pourhabibi-Zarandi F, Shojaei-Zarghani S, Rafraf M.Int J Clin Pract. 2021 Oct;75(10):e14280. doi: 10.1111/ijcp.14280. Epub 2021 May 24.

The Clinical Use of Curcumin for the Treatment of Rheumatoid Arthritis: A Systematic Review of Clinical Trials.
Bagherniya M, Darand M, Askari G, Guest PC, Sathyapalan T, Sahebkar A.Adv Exp Med Biol. 2021;1291:251-263. doi: 10.1007/978-3-030-56153-6_15.

Effects of curcumin supplementation on inflammatory biomarkers in patients with Rheumatoid Arthritis and Ulcerative colitis: A systematic review and meta-analysis.
Ebrahimzadeh A, Abbasi F, Ebrahimzadeh A, Jibril AT, Milajerdi A.Complement Ther Med. 2021 Sep;61:102773. doi: 10.1016/j.ctim.2021.102773. Epub 2021 Aug 31.

Efficacy and Safety of Curcumin and Curcuma longa Extract in the Treatment of Arthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trial.
Zeng L, Yang T, Yang K, Yu G, Li J, Xiang W, Chen H.Front Immunol. 2022 Jul 22;13:891822. doi: 10.3389/fimmu.2022.891822. eCollection 2022.

Curcumin and Curcuma longa Extract in the Treatment of 10 Types of Autoimmune Diseases: A Systematic Review and Meta-Analysis of 31 Randomized Controlled Trials.
Zeng L, Yang T, Yang K, Yu G, Li J, Xiang W, Chen H.Front Immunol. 2022 Aug 1;13:896476. doi: 10.3389/fimmu.2022.896476. eCollection 2022.


 
Potential Benefits of Curcumin in Rheumatoid Arthritis.
Sotebeer M, White ND.Am J Lifestyle Med. 2022 Aug 7;16(6):684-686. doi: 10.1177/15598276221116063. eCollection 2022 Nov-Dec.

Effect of curcumin on rheumatoid arthritis: a systematic review and meta-analysis.
Kou H, Huang L, Jin M, He Q, Zhang R, Ma J.Front Immunol. 2023 May 31;14:1121655. doi: 10.3389/fimmu.2023.1121655. eCollection 2023.

Efficacy and safety of curcumin in maintaining remission during disease-modifying antirheumatic drug withdrawal in rheumatoid arthritis at 52 weeks: a phase III double-blind, randomized placebo-controlled trial.
Bhat SS, Ahmed S, Reji R, Mehta P, Paul A, Mohanan M, Babu S, Vinayak B, Vijayan A, Nalianda KK, Joseph S, Narayanan K, Padmaja R, Alex G, Shenoy P.Rheumatol Int. 2023 Dec;43(12):2193-2200. doi: 10.1007/s00296-023-05417-z. Epub 2023 Aug 31.

The efficacy of curcumin supplementation on serum total antioxidant capacity, malondialdehyde, and disease activity in women with rheumatoid arthritis: A randomized, double-blind, placebo-controlled clinical trial.
Pourhabibi-Zarandi F, Rafraf M, Zayeni H, Asghari-Jafarabadi M, Ebrahimi AA.Phytother Res. 2024 Jul;38(7):3552-3563. doi: 10.1002/ptr.8225. Epub 2024 May 3.

Immunomodulatory effects of novel nano micelle based curcumin in rheumatoid arthritis patients: A double blind randomized clinical trial.
Khamar F, Atabaki M, Samadi M, Reisi M, Sandoughi M.Rheumatol Immunol Res. 2025 Jan 9;5(4):227-234. doi: 10.1515/rir-2024-0031. eCollection 2024 Dec.

Effect of curcumin on inflammatory markers and disease activity in patients with rheumatoid arthritis: A meta-analysis.
Zhang F, Niu B.Medicine (Baltimore). 2025 Nov 28;104(48):e46177. doi: 10.1097/MD.0000000000046177.

Effects of curcumin and Curcuma longa extract on inflammatory biomarkers in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE): a systematic review and meta-analysis of randomized controlled trials.
Liu AJ, Wu PC, Chen YP, Chu HT, Chang HH.Inflamm Res. 2025 Dec 10;75(1):2. doi: 10.1007/s00011-025-02135-z.

Curcumin for the clinical treatment of rheumatoid arthritis: a systematic review and meta-analysis of placebo-controlled randomized clinical trials.
Fan Y, Yi Z, Mao S, Wen J, Zhang J, Zhang Q, Liu R.Front Immunol. 2026 Jan 12;16:1726157. doi: 10.3389/fimmu.2025.1726157. eCollection 2025.

In addition, to rheumatoid arthritis, there is also lots of research reporting benefit of curcumin in osteoartritis - the more common form of arthritis

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