Although a study from 2012 reported no benefit of vitamin D supplementation for reducing fatigue those with MS, this study used large dose of vitamin D3 (20,000IU) given once per week, while the best evidence is for moderate and daily dosing.


A 2014 study reported that reported that higher personal sun exposure was associated with lower fatigue.



A 2015 gold standard study using the form of vitamin D produced by our liver when we are exposed to sun or ingest vitamin D, reported decreases in fatigue compared to placebo.


A 2019 study from turkey reported that ‘after vitamin D supplementation, health-related quality of life and fatigue scores improved significantly’ among persons with MS.


In addition to vitamin D, other supplements which are scientifically demonstrated to improve MS include:


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