Evidence-Based, Non-Hormonal Nutritional Strategies for Uterine Fibroids and Fertility - What Does the Research Say? Nutrients for Fibroids and Fertility
Written by fertility nutrition expert, Dr. Conor Kerley
Dr. Conor Kerley is a multi-award winning nutrition researcher, leading clinician as well as a member of the European Fertility Society and European Society of Human Reproduction and Embryology (ESHRE)
Uterine fibroids (leiomyomas) affect up to 70% of women by age 50. While many are asymptomatic, fibroids can impair implantation, increase miscarriage risk, and reduce fertility outcomes.
Conventional treatment often involves surgery or hormonal therapy — both of which may not be ideal for women actively trying to conceive.
Emerging human research suggests that specific nutrients may influence fibroid growth, inflammation, oxidative stress, and fibrosis — offering potential non-hormonal support.
The nutrients which have been shown in human research studies to improve uterine fibroids (Leiomyomas) include:
1. Coenzyme Q10 – a 2024 study demonstrated that coenzyme Q10 could slow fibroid growth and reduce fibrotic tissue buildup and even potentially offer a non-hormonal treatment strategy for fibroids
2. EGCG (Epigallocatechin Gallate) from green tea extract
3. Inositol (as D-chiro-inositol) a 2024 study reported benefits from combining EGCG with vitamin D and D-chiro-inositol, including improved outcomes without any side effects
4. N-acetyl cysteine (NAC)– A 2021 study in women with uterine fibroids, reported that daily NAC supplementation could decrease fibroid volume by over 25% leading the researchers to recommend the use of NAC as a non-hormonal therapy for uterine fibroids, calling NAC feasible and effective the reduction of fibroid volume.
5. Vitamin B6 (pyridoxine)
6. Vitamin D3 (cholecalciferol)
These 6 nutrients can affect:
· mitochondrial function
· oxidative stress
· angiogenesis (new blood vessel growth),
· cell proliferation (the rate at which cell multiply),
· hormone metabolism (especially oestrogen and progesterone)
Therefore these 6 nutrients can affect and reduce fibrosis or scarring, defined as the accumulation of excess extracellular matrix component). Less fibrosis = slowing or stopping or fibroids!
Ladies with fibroids actively trying to conceive or planning a pregnancy in the future, should consider supplementing these 6 nutrients as well as specific nutrients to improve egg quality, such as:
· Alpha lipoic acid
· B vitamins, especially B6, B9 (as methylfolate) and B12
· Iodine
· Myo-inositol
· Omega 3
· Selenium
Implementing these nutrients individually can be complex, requiring multiple supplements and careful dosing.
Fertility Phix is an all in one fertility supplement and was formulated to provide these research-backed nutrients in evidence-informed doses, alongside additional compounds that support egg quality and mitochondrial function.
Note, fertility issues are NOT female only. About half of fertility issues can be related to the male partner. If you are a lady trying to conceive, make sure your male partner has been tested, is following a fertility friendly lifestyle and check our these blogs:
Nutrients for Male Fertility, Sperm Quality and sperm count - The Science
Nutrients for Male Fertility, Sperm Quality and sperm motility - The Science
Nutrients for Male Fertility, Sperm Quality and sperm morphology - The Science
Nutrients for Male Fertility, Sperm Quality and sperm DNA fragmentation - The Science
Nutrients for Male Fertility, Sperm Quality and varicocele - The Science
In addition to uterine fibroids, other common conditions contributing to fertility issues in women, include:
Advanced age (over 35 but especially over 40)
Antiphospholipid syndrome
Fibroids
Hypothalamic amenorrhea
Lupus
PCOS
Premature ovarian insufficiency (POI)
Thyroid issues, especially Hashimoto's or autoimmune thyroiditis
Please note: This blog does NOT represent medical advice
Always consult your GP or fertility specialist before starting supplements, particularly if undergoing assisted reproductive treatment.
